H0135
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H0135
Sigma
Hydrocortisone
powder, γ-irradiated, cell culture tested
| Synonym: | 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M |
| CAS Number: | 50-23-7 |
| Linear Formula: | C21H30O5 |
| Molecular Weight: | 362.46 |
| Beilstein Registry Number: | 1354819 |
| EC Number: | 200-020-1 |
| MDL number: | MFCD00011654 |
| PubChem Substance ID: | 24895394 |
Description
| Reconstitution | To prepare 50 μg/mL stock solution; add 1 mL absolute ethanol, gently swirl to dissolve, add 19 mL sterile medium while mixing. |
| Physical form | powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw |
| Biochem/physiol Actions | Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency. |
Properties
| sterility | γ-irradiated |
| form | powder |
| potency | 0.004-5 μg/mL |
| mp | 211-214 °C(lit.) |
| suitability | cell culture tested |
| Gene Information | human ... ABCB1(5243), CYP3A4(1576), SERPINA6(866) |
| rat ... Ar(24208), Nr3c1(24413) | |
| mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 63 |
| Safety Statements | 36/37 |
| WGK Germany | 3 |
| RTECS | GM8925000 |
Related Products
| Related product | H6909, Hydrocortisone solution |
References
| Merck | Merck 13,4808 |
| Beilstein | Beil. 8,IV,3422 |
| reference | Corp MSDS 1 (1), 1894:B / FT-IR 2 (3), 4233:A / FT-NMR 1 (3), 584:C / RegBook 1 (2), 2863:G / Sigma FT-IR 1 (1), 1259:B / Structure Index 1, 458:D:6 |
